Methylamine → HCID 21037302, compound

HRID 13505Notes

Reaction equation

HRID 13505 reaction equation
CO[C:3]([C:5]1[CH:6]=[N:7][CH:8]=[C:9]([O:11][C:12]2[CH:29]=[CH:28][C:15]3[N:16]([CH3:27])[C:17]([NH:19][C:20]4[CH:25]=[CH:24][C:23]([Br:26])=[CH:22][CH:21]=4)=[N:18][C:14]=3[CH:13]=2)[CH:10]=1)=[O:4].[CH3:30][NH2:31]>>[Br:26][C:23]1[CH:22]=[CH:21][C:20]([NH:19][C:17]2[N:16]([CH3:27])[C:15]3[CH:28]=[CH:29][C:12]([O:11][C:9]4[CH:10]=[C:5]([C:3]([NH:31][CH3:30])=[O:4])[CH:6]=[N:7][CH:8]=4)=[CH:13][C:14]=3[N:18]=2)=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 22040538Methyl5-{2-[(4-bromophenyl)amino]-1-methylbenzimidazol-5-yloxy}pyridine-3-carboxylate

Product 1

HCID 21037302HCID 21037302, compound

Procedure

To a solution of methyl5-{2-[(4-bromophenyl)amino]-1-methylbenzimidazol-5-yloxy}pyridine-3-carboxylate in added methylamine and the resulting mixture was stirred at ambient temperature for 16 h. It was then concentrated and purified by preparative chromatography to yield (5-{2-[(4-bromophenyl)amino]-1-methylbenzimidazol-5-yloxy)-(3-pyridyl))-N-methylcarboxamide. MS: MH+=452.

Workup

  1. concentrationIt was then concentrated
  2. custompurified by preparative chromatography

Sources & evidence

ORD record
ord-ccc2f8be082f4523b3ce8544020f50b3
Source dataset
uspto-grants-2010_06
Patent number
US07728010B2

Reaction notes

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