Pyridoxine Hydrochloride → Pyridoxine

HRID 1350549Notes

Reaction equation

HRID 1350549 reaction equation
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][OH:9])=[C:4]([CH2:10][OH:11])[C:3]=1[OH:12].Cl>O>[CH3:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][OH:9])=[C:4]([CH2:10][OH:11])[C:3]=1[OH:12]

Participants

3

Reactant 1

HCID 6019Pyridoxine Hydrochloride

Product 1

HCID 1054Pyridoxine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

In a second alternative and preferred workup, the reaction mixture (following complete conversion to compound (C)) is cooled to 20° C. and diluted with water (approximately 2.80 L of water for every 1 kg of starting pyridoxine HCl). After phase separation the organic phase is washed with water. The combined aqueous phases are reextracted twice with TBME. The combined TBME phases are washed once with saturated NaHCO3-solution and once with diluted brine. The MTBE-product solution is concentrated to a concentration of about 50% and stored at room temperature until it is further converted. If this second alternative workup is used, the volume of MTBE in the synthetic step is preferably reduced by about 26%.

Workup

  1. customAfter phase separation the organic phase
  2. washis washed with water
  3. washThe combined TBME phases are washed once with saturated NaHCO3-solution and once with diluted brine
  4. concentrationThe MTBE-product solution is concentrated to a concentration of about 50%
  5. customstored at room temperature until it

Sources & evidence

ORD record
ord-ffc973ba8df24903b7496f16c866375a
Source dataset
uspto-grants-2007_05
Patent number
US07214799B2

Reaction notes

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