Ammonia → HCID 58861252, compound

HRID 1350574Notes

Reaction equation

HRID 1350574 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:12]1[CH2:17][CH2:16][CH:15]([CH2:18][CH2:19][N:20]3[C:24](=[O:25])[CH2:23][O:22][C:21]3=[O:26])[CH2:14][CH2:13]1)[CH:6]=[CH:5]2.[NH3:27]>CO>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:12]1[CH2:13][CH2:14][CH:15]([CH2:18][CH2:19][NH:20][C:21](=[O:26])[O:22][CH2:23][C:24]([NH2:27])=[O:25])[CH2:16][CH2:17]1)[CH:6]=[CH:5]2

Participants

4

Reactant 2

HCID 222AmmoniaHCID 21096966HCID 21096966, compound

Product 1

HCID 58861252HCID 58861252, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The process is performed according to the procedure described in Example 3 (step 3.4). Starting with 1.28 g (3.42 mmol) of 3-{2-[1-(6-chloro-2-quinolyl)-4-piperidyl]ethyl}-1,3-oxazolidine-2,4-dione, obtained in step 10.3, and 22.10 ml (154.08 mmol) of a solution (7M) of aqueous ammonia in methanol, and after crystallization from ethanol, 0.64 g of pure product is obtained in the form of a white solid.

Sources & evidence

ORD record
ord-f90413af9eeb4e11ba0224490c759a78
Source dataset
uspto-grants-2007_05
Patent number
US07214798B2

Reaction notes

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