Ammonia → 1-(Allyloxy)-3-aminopropan-2-ol

Participants

Reaction Steps

Ammonium hydroxide (28%–30% (about 14.82 mol) of ammonia in water, 202 mL, 3 mol) was charged to a one liter, one-neck, round-bottom flask that was cooled in an ice bath. To the above solution allyl glycidyl ether (57.07 g, 0.5 mol) was added dropwise at 0° C. The mixture was allowed to warm up to room temperature and stirred for two days after completion of the allyl glycidyl ether addition. 3-Allyloxy-2-hydroxy-propylamine was separated by distillation at 76° C.–82° C. under 0–1 mbar as a clear liquid (˜33 g).

Provenance & Evidence