Ammonia → 1-Amino-3-(2-propen-1-yloxy)-2-propanol
Reaction equation
[OH-].[NH4+:2].N.[CH2:4]([O:8][CH2:9][CH:10]=[CH2:11])[CH:5]1[O:7][CH2:6]1>>[CH2:9]([O:8][CH2:4][CH:5]([OH:7])[CH2:6][NH2:2])[CH:10]=[CH2:11]Participants
4
Procedure
Ammonium hydroxide (28%–30% (about 14.82 mol) of ammonia in water, 202 mL, 3 mol) was charged to a one liter, one-neck, round-bottom flask that was cooled in an ice bath. To the above solution allyl glycidyl ether (57.07 g, 0.5 mol) was added dropwise at 0° C. The mixture was allowed to warm up to room temperature and stirred for two days after completion of the allyl glycidyl ether addition. 3-Allyloxy-2-hydroxy-propylamine was separated by distillation at 76° C.–82° C. under 0–1 mbar as a clear liquid (˜33 g).
Workup
- temperaturewas cooled in an ice bath
- custom3-Allyloxy-2-hydroxy-propylamine was separated by distillation at 76° C.–82° C. under 0–1 mbar as a clear liquid (˜33 g)
Sources & evidence
- ORD record
- ord-bc64c61b49ce4690a4aefedd09313088
- Source dataset
- uspto-grants-2007_05
- Patent number
- US07214809B2
Reaction notes
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