3-Azido-4-methylbenzoic acid → 3-[4-(5-Methoxy-pyridin-3-yl)-[1,2,3]triazol-1-yl]-4-methyl-benzoic acid

HRID 1350665Notes

Reaction equation

HRID 1350665 reaction equation
[N:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[CH3:13])[C:7]([OH:9])=[O:8])=[N+:2]=[N-:3].[C:14]([C:16]1[CH:17]=[C:18]([O:22][CH3:23])[CH:19]=[N:20][CH:21]=1)#[CH:15].ClC1N=CC(C2N=NN(C3C=C(C=CC=3C)C(O)=O)C=2)=CC=1>>[CH3:23][O:22][C:18]1[CH:17]=[C:16]([C:14]2[N:3]=[N:2][N:1]([C:4]3[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=3[CH3:13])[C:7]([OH:9])=[O:8])[CH:15]=2)[CH:21]=[N:20][CH:19]=1

Participants

4

Reactant 3

HCID 179730913-Azido-4-methylbenzoic acidHCID 210972923-[4-(6-Chloro-pyridin-3-yl)-1,2,3-triazol-1-yl]-4-methyl-benzoic acidHCID 210973493-Ethynyl-5-methoxypyridine

Product 1

HCID 210972913-[4-(5-Methoxy-pyridin-3-yl)-[1,2,3]triazol-1-yl]-4-methyl-benzoic acid

Procedure

3-[4-(5-Methoxy-pyridin-3-yl)-[1,2,3]triazol-1-yl]-4-methyl-benzoic acid was prepared from 3-azido-4-methyl benzoic acid and 5-ethynyl-3-methoxy pyridine in the same manner as 3-[4-(6-chloro-pyridin-3-yl)-1,2,3-triazol-1-yl]-4-methyl-benzoic acid (Example 1).

Sources & evidence

ORD record
ord-1e6d443a37b14e1781d47081378e88d0
Source dataset
uspto-grants-2007_05
Patent number
US07214802B2

Reaction notes

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