Cyclopropylamine → N-Cyclopropyl-5-ethynyl-2-pyridinamine

HRID 1350693Notes

Reaction equation

HRID 1350693 reaction equation
[CH:1]1([NH:4][C:5]2[CH:10]=[CH:9][C:8](I)=[CH:7][N:6]=2)[CH2:3][CH2:2]1.Cl[C:13]1[CH:18]=CC(C#C)=CN=1.ClC1C=CC(I)=CN=1.C1(N)CC1.[CH:33]1([CH2:36][NH:37][C:38]2[CH:43]=[CH:42][C:41]([I:44])=[CH:40][N:39]=2)[CH2:35]C1>>[CH:1]1([NH:4][C:5]2[CH:10]=[CH:9][C:8]([C:13]#[CH:18])=[CH:7][N:6]=2)[CH2:3][CH2:2]1.[CH:36]1([NH:37][C:38]2[CH:43]=[CH:42][C:41]([I:44])=[CH:40][N:39]=2)[CH2:33][CH2:35]1

Participants

7

Reactant 5

HCID 69828CyclopropylamineHCID 43971762-Chloro-5-iodopyridineHCID 106542812-Chloro-5-ethynylpyridineHCID 21097356HCID 21097356, compoundHCID 21097359HCID 21097359, compound

Product 2

HCID 21097355N-Cyclopropyl-5-ethynyl-2-pyridinamineHCID 21097356HCID 21097356, compound

Procedure

Cyclopropyl-(5-ethynyl-pyridin-2-yl)-amine was prepared from cyclopropyl-(5-iodo-pyridin-2-yl)-amine in the same manner as 2-chloro-5-ethynyl-pyridine (Example 1). Cyclopropyl-(5-iodo-pyridin-2-yl)-amine was prepared from 2-chloro-5-iodo-pyridine and cyclopropyl amine in the same manner as cyclopropylmethyl-(5-iodo-pyridin-2-yl)-amine (Example 2).

Sources & evidence

ORD record
ord-eb347b7f6ed647c182c5418809aca473
Source dataset
uspto-grants-2007_05
Patent number
US07214802B2

Reaction notes

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