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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1350693Generated: October 30, 2026

Cyclopropylamine → N-Cyclopropyl-5-ethynyl-2-pyridinamine

https://huagongshe.com/reaction/1350693

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclopropylamineHCID 69828—
Reactant2-Chloro-5-iodopyridineHCID 4397176—
Reactant2-Chloro-5-ethynylpyridineHCID 10654281—
ReactantHCID 21097356HCID 21097356—
ReactantHCID 21097359HCID 21097359—
ProductN-Cyclopropyl-5-ethynyl-2-pyridinamineHCID 21097355—
ProductHCID 21097356HCID 21097356—

Reaction Steps

Cyclopropyl-(5-ethynyl-pyridin-2-yl)-amine was prepared from cyclopropyl-(5-iodo-pyridin-2-yl)-amine in the same manner as 2-chloro-5-ethynyl-pyridine (Example 1). Cyclopropyl-(5-iodo-pyridin-2-yl)-amine was prepared from 2-chloro-5-iodo-pyridine and cyclopropyl amine in the same manner as cyclopropylmethyl-(5-iodo-pyridin-2-yl)-amine (Example 2).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07214802B2
Source datasetuspto-grants-2007_05
ORD IDord-eb347b7f6ed647c182c5418809aca473
Source noteuspto-grants-2007_05