HCID 21097232, compound → HCID 21097233, compound

HRID 1350796Notes

Reaction equation

HRID 1350796 reaction equation
[CH2:1]([C:3]1[N:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:6]=[CH:5][C:4]=1[CH:14]([OH:16])[CH3:15])[CH3:2]>C1COCC1.O=[Mn]=O>[CH2:1]([C:3]1[N:7]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:6]=[CH:5][C:4]=1[C:14](=[O:16])[CH3:15])[CH3:2]

Participants

4

Reactant 1

HCID 21097232HCID 21097232, compound

Product 1

HCID 21097233HCID 21097233, compoundYield 98.6%

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 7.9 g (36.5 mmol) of 1-(5-ethyl-1-phenyl-1H-pyrazol-4-yl)-ethanol in 100 mL THF was stirred at rt over 24 g of activated MnO2 for 23 h. The mixture was filtered through Celite and concentrated to give 1-(5-ethyl-1-phenyl-1H-pyrazol-4-yl)-ethanone (7.71 g). ESI MS m/z 215 [C13H14N2O+H]+.

Workup

  1. filtrationThe mixture was filtered through Celite
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-101a31a6772342a9802695092d1922f8
Source dataset
uspto-grants-2007_05
Patent number
US07214802B2

Reaction notes

Loading…