HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorophenol → 4-Tert-butyl-3-fluorophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorophenol | HCID 9743 | — |
| Reactant | tert-Butyl methyl ether | HCID 15413 | — |
| Catalyst | Zirconium chloride (ZrCl4), (T-4)- | HCID 9856075 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Tert-butyl-3-fluorophenol | HCID 20583424 | 55% |
Reaction Steps
To a suspension of zirconium tetrachloride (1.2 g, 5 mmol) in methylene dichloride (15 ml), methyl tert-butyl ether (0.44 g, 5 mmol), 3-fluorophenol (0.56 g, 5 mmol) were treated in the same procedure described in Example 3(a) to furnish 458 mg (55% yield) of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07214824B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-ff8dd3fefc0141a19c0e37b27d4aa1e1 |
| Source note | uspto-grants-2007_05 |