3-Fluorophenol → 4-Tert-butyl-3-fluorophenol

HRID 1350821Notes

Reaction equation

HRID 1350821 reaction equation
[C:1](OC)([CH3:4])([CH3:3])[CH3:2].[F:7][C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1>C(Cl)Cl.[Cl-].[Cl-].[Cl-].[Cl-].[Zr+4]>[C:1]([C:13]1[CH:12]=[CH:11][C:10]([OH:14])=[CH:9][C:8]=1[F:7])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 97433-FluorophenolHCID 15413tert-Butyl methyl ether

Product 1

HCID 205834244-Tert-butyl-3-fluorophenolYield 55%

Reagents, catalysts & solvents 2

HCID 9856075Zirconium chloride (ZrCl4), (T-4)-CatalystHCID 6344DichloromethaneSolvent

Procedure

To a suspension of zirconium tetrachloride (1.2 g, 5 mmol) in methylene dichloride (15 ml), methyl tert-butyl ether (0.44 g, 5 mmol), 3-fluorophenol (0.56 g, 5 mmol) were treated in the same procedure described in Example 3(a) to furnish 458 mg (55% yield) of the title compound as a white solid.

Workup

  1. additionwere treated in the same procedure

Sources & evidence

ORD record
ord-ff8dd3fefc0141a19c0e37b27d4aa1e1
Source dataset
uspto-grants-2007_05
Patent number
US07214824B2

Reaction notes

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