Trifluoroacetic acid → HCID 21097510, compound

HRID 1350831Notes

Reaction equation

HRID 1350831 reaction equation
[CH3:1][C:2]1([CH3:21])[CH2:11][CH2:10][CH2:9][C:8]2[CH:7]=[C:6]([O:12][CH2:13][C:14]([O:16]C(C)(C)C)=[O:15])[CH:5]=[CH:4][C:3]1=2.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:1][C:2]1([CH3:21])[CH2:11][CH2:10][CH2:9][C:8]2[CH:7]=[C:6]([O:12][CH2:13][C:14]([OH:16])=[O:15])[CH:5]=[CH:4][C:3]1=2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58640416HCID 58640416, compound

Product 1

HCID 21097510HCID 21097510, compoundYield 64.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

A mixture of tert-butyl [(5,5-dimethyl-5,6,7,8-tetrahydronaphthalen-2-yl)oxy]acetate (2.8 g, 9.6 mmol), trifluoroacetic acid (10.0 ml) and methylene dichloride (20 ml) was stirred for 2 hours at 0° C. After being concentrated under reduced pressure, the crude residue was triturated using hexane and collected by filtration to give 1.45 g of the title compound as a white solid, which was used for further reaction without purification.

Workup

  1. concentrationAfter being concentrated under reduced pressure
  2. customthe crude residue was triturated
  3. filtrationcollected by filtration

Sources & evidence

ORD record
ord-882a3efffcfc4825a580fee7a49f057b
Source dataset
uspto-grants-2007_05
Patent number
US07214824B2

Reaction notes

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