反应详情

温度

65 °C

To an acetone (5 ml) solution of 4-tert-butyl-3-chlorophenol (440 mg, 2.4 mmol) were added potassium carbonate (994 mg, 7.2 mmol) and tert-butyl bromoacetate (0.7 ml, 4.8 mmol). The stirred mixture was refluxed at 65° C. for 14 hours. The precipitate was filtered off and washed with acetone. The filtrate was concentrated under reduced pressure to give a residue, which was applied to a silica gel chromatography column and eluted with ethyl acetate/hexane= 1/9 to furnish 0.83 g (100% yield) of the title as a colorless oil.

1. filtrationThe precipitate was filtered off
2. washwashed with acetone
3. concentrationThe filtrate was concentrated under reduced pressure
4. customto give a residue, which
5. washeluted with ethyl acetate/hexane= 1/9
6. customto furnish 0.83 g (100% yield) of the title as a colorless oil