反应详情

To a methylene dichloride (2.0 ml) solution of tert-butyl [4-tert-butyl-2-(piperidin-1-ylmethyl)phenoxy]acetate (75 mg, 0.21 mmol), trifluoroacetic acid (0.2 ml, 2.7 mmol) was added at ambient temperature under nitrogen atmosphere. After being stirred for 15 hours, additional trifluoroacetic acid (1.0 ml, 13.5 mmol) was added. After being stirred additionally for 10 hours, the resulting mixture was concentrated under reduced pressure and azeotrope with toluene to furnish 111 mg of the title compound as slightly yellow oil, which was used for the next reaction without further purification.

1. stirringAfter being stirred additionally for 10 hours
2. concentrationthe resulting mixture was concentrated under reduced pressure and azeotrope with toluene