HCID 58640407, compound → HCID 58640419, compound

HRID 1350870Notes

Reaction equation

HRID 1350870 reaction equation
[C:1]([C:5]1[CH:26]=[CH:25][C:8]([O:9][CH2:10][C:11]([NH:13][C@@H:14]([C:16]2[CH:21]=[CH:20][C:19]([N+:22]([O-])=O)=[CH:18][CH:17]=2)[CH3:15])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[NH2:22][C:19]1[CH:20]=[CH:21][C:16]([C@H:14]([NH:13][C:11](=[O:12])[CH2:10][O:9][C:8]2[CH:7]=[CH:6][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:26][CH:25]=2)[CH3:15])=[CH:17][CH:18]=1

Participants

4

Reactant 1

HCID 58640407HCID 58640407, compound

Product 1

HCID 58640419HCID 58640419, compoundYield 128.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 2-(4-tert-butylphenoxy)-N-[(1R)-1-(4-nitrophenyl)ethyl]acetamide (360 mg, 1.0 mmol) and 10% Pd—C (50 mg) in methanol (10 ml) was stirred under H2 balloon pressure for 1 hour at ambient temperature. Then, filtration to remove 10% Pd—C, evaporation gave 420 mg of the title compound as yellow oil.

Workup

  1. filtrationThen, filtration
  2. customto remove
  3. custom10% Pd—C, evaporation

Sources & evidence

ORD record
ord-19e561e739c24ffe905ba534957468d5
Source dataset
uspto-grants-2007_05
Patent number
US07214824B2

Reaction notes

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