反应详情

To an ice-cold, stirred mixture of 4-(benzyloxy)-N-propylbutanamide (2.59 g, 11.0 mmol) in THF (8 mL) is added lithium aluminum hydride (0.54 g, 14.3 mmol). The reaction mixture is heated to 40–50 degrees C. for 5 hours. The cooled reaction mixture is quenched with water (0.5 mL), sodium hydroxide (2 N, 1.0 mL), and saline (0.5 mL) then diluted with ether (30 mL). The precipitate that formed is filtered off, and the ether phase dried over magnesium sulfate, filtered, and concentrated under reduced pressure to give N-[4-(benzyloxy)butyl]-N-propylamine (2.41 g), APCI-MS (m/z): 222 [M+H]+.

1. temperatureThe reaction mixture is heated to 40–50 degrees C
2. customThe cooled reaction mixture
3. customis quenched with water (0.5 mL), sodium hydroxide (2 N, 1.0 mL), and saline (0.5 mL)
4. additionthen diluted with ether (30 mL)
5. customThe precipitate that formed
6. filtrationis filtered off
7. dry with materialthe ether phase dried over magnesium sulfate
8. filtrationfiltered
9. concentrationconcentrated under reduced pressure