HCID 21097609, compound → HCID 21097608, compound

HRID 1351036Notes

Reaction equation

HRID 1351036 reaction equation
[F:1][C:2]([F:40])([F:39])[CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][O:10][CH2:11][CH2:12][O:13][CH2:14][CH2:15][O:16][CH2:17][CH2:18][O:19][CH2:20][CH2:21][O:22][CH2:23][CH2:24][O:25][CH2:26][CH2:27][O:28][CH2:29][CH2:30][O:31]CC1C=CC=CC=1>[Pd].C(O)(=O)C.C(O)C>[F:1][C:2]([F:39])([F:40])[CH2:3][O:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][O:10][CH2:11][CH2:12][O:13][CH2:14][CH2:15][O:16][CH2:17][CH2:18][O:19][CH2:20][CH2:21][O:22][CH2:23][CH2:24][O:25][CH2:26][CH2:27][O:28][CH2:29][CH2:30][OH:31]

Participants

4

Reactant 1

HCID 21097609HCID 21097609, compound

Product 1

HCID 21097608HCID 21097608, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 18476134Acetic acid ethanolSolvent

Procedure

A stirred solution of the product of step (b) (0.97 g) and 10% palladium on carbon (100 mg) in acetic acid:ethanol (1:9, 20 mL) was placed under an atmosphere of hydrogen at 20° C. for 2 hours. The reaction mixture was filtered through a pad of celite and the solvent was removed in vacuo to give the title compound (780 mg). LC retention time 2.45 mins

Workup

  1. filtrationThe reaction mixture was filtered through a pad of celite
  2. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-c4496e39d71d41abbbdc4d4be4a88fa1
Source dataset
uspto-grants-2007_05
Patent number
US07217409B2

Reaction notes

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