Water → 2-Phenoxybenzyl alcohol

HRID 1351085Notes

Reaction equation

HRID 1351085 reaction equation
[O:1]([C:8]1[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10](O)=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>O1CCCC1>[O:1]([C:8]1[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=1[CH2:10][OH:11])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 752372-Phenoxybenzoic acidHCID 21226445Aluminium lithium hydride

Product 1

HCID 36601112-Phenoxybenzyl alcoholYield 84.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-Phenoxybenzoic acid (324 mg) was added gently to a suspension of lithium aluminum hydride (172 mg) in tetrahydrofuran (10 mL), and the mixture was stirred at room temperature overnight. Water (1 mL) was added gently to the reaction mixture, and the resulting mixture was stirred for 30 minutes. The reaction mixture was dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to give the title compound (256 mg).

Workup

  1. stirringthe resulting mixture was stirred for 30 minutes
  2. dry with materialThe reaction mixture was dried over anhydrous magnesium sulfate
  3. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-f464bf93ae284379afba2fad3c992f43
Source dataset
uspto-grants-2007_05
Patent number
US07217697B2

Reaction notes

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