2-Morpholinoethylamine → HCID 21098053, compound

HRID 1351151Notes

Reaction equation

HRID 1351151 reaction equation
[Br:1][C:2]1[C:10]2[C:5](=[N:6][C:7](S(C)(=O)=O)=[N:8][CH:9]=2)[N:4]([CH3:15])[N:3]=1.[NH2:16][CH2:17][CH2:18][N:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[Br:1][C:2]1[C:10]2[C:5](=[N:6][C:7]([NH:16][CH2:17][CH2:18][N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[N:8][CH:9]=2)[N:4]([CH3:15])[N:3]=1

Participants

3

Reactant 2

HCID 4082852-MorpholinoethylamineHCID 210980553-Bromo-6-(methanesulfonyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

Product 1

HCID 21098053HCID 21098053, compound

Procedure

Prepared as described above in Example 8 starting from 3-bromo-6-methanesulfonyl-1-methyl-1H-pyrazolo[3,4-d]pyrimidine and N-aminoethylmorpholine to give the title compound (3-bromo-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-(2-morpholin-4-yl-ethyl)-amine; 1H-NMR (DMSO): δ 2.43 (m, 4H), 2.50 (m, 2H), 3.47 (m, 2H), 3.55 (m, 2H), 3.77 (s, 3H), 7.61 (br s, 1H), 8.63 (s, 1H); LC/MS (m/e)=340.21 (MH+), Rt=1.13 min.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-dbda1902231e48a4aee6301ddb854f10
Source dataset
uspto-grants-2007_05
Patent number
US07217710B2

Reaction notes

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