HCID 68978662, compound → HCID 21098044, compound

HRID 1351160Notes

Reaction equation

HRID 1351160 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:22]3[C:17](=[N:18][C:19]([NH:23][CH2:24][CH2:25][N:26]4[CH2:31][CH2:30][O:29][CH2:28][CH2:27]4)=[N:20][CH:21]=3)[N:16]([CH3:32])[N:15]=2)=[CH:10][C:9]=1[CH3:33])(C)(C)C>FC(F)(F)C(O)=O>[NH2:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:22]3[C:17](=[N:18][C:19]([NH:23][CH2:24][CH2:25][N:26]4[CH2:27][CH2:28][O:29][CH2:30][CH2:31]4)=[N:20][CH:21]=3)[N:16]([CH3:32])[N:15]=2)=[CH:10][C:9]=1[CH3:33]

Participants

3

Reactant 1

HCID 68978662HCID 68978662, compound

Product 1

HCID 21098044HCID 21098044, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

{2-Methyl-4-[1-methyl-6-(2-morpholin-4-yl-ethylamino)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-phenyl}-carbamic acid tert-butyl ester (468 mg, 1 mmol) was dissolved in 10 mL of trifluoroacetic acid. After 1 hour the reaction mixture was evaporated, and methanol (10 mL) followed by water (10 mL) was added. The reaction mixture was then neutralised with 1 M NaOH to pH˜8 and product was filtered and dryed to give pure [3-(4-amino-3-methyl-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-morpholin-4-yl-ethyl)-amine; LC/MS (m/e)=368.2 (MH+), Rt=1.02 min.

Workup

  1. customAfter 1 hour the reaction mixture was evaporated
  2. additionwas added
  3. filtrationwas filtered

Sources & evidence

ORD record
ord-eb642c41ca434d52933feca11fa4b4fb
Source dataset
uspto-grants-2007_05
Patent number
US07217710B2

Reaction notes

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