反应详情

A solution of (6-allyloxy-7-methoxy-quinazolin-4-yl)-(4-chloro-phenyl)-amine (0.50 g, 1.46 mmol) (from Example 16, Step C, supra) in o-xylene (50 mL) was heated at 150° C. for 7 hours. At the end of this period, TLC analysis indicated almost complete consumption of the starting material and the formation of desired product as the major spot. The solvent was evaporated and the residue was purified by chromatography using EtOAc/Et3N (1:0.04) as eluent to give the desired 5-allyl-4-(4-chloro-phenylamino)-7-methoxy-quinazolin-6-ol as an off white solid. (Yield 0.4 g, 80%).

1. customconsumption of the starting material
2. customThe solvent was evaporated
3. customthe residue was purified by chromatography