反应详情

4-Fluorobenzylbromide (0.37 mL, 2.97 mmol) was added dropwise to a solution of 84AF15 (289 mg, 1.13 mmol) in dry DMF (50 mL) at rt. The mixture was stirred at rt for 6 days under argon atmosphere. The solvent was removed by evaporation under reduced pressure and the residue partitioned between chloroform and water. The organic layer was dried over sodium sulphate, filtered and concentrated in vacuo. Purification of the residue by column chromatography on silica gel, eluting with dichloromethane, afforded the desired compound (160 mg, 39%).

1. customThe solvent was removed by evaporation under reduced pressure
2. customthe residue partitioned between chloroform and water
3. dry with materialThe organic layer was dried over sodium sulphate
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customPurification of the residue by column chromatography on silica gel
7. washeluting with dichloromethane