p-Fluorophenethylamine → HCID 21098561, Verbindung

HRID 1351256Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1351256
[F:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH2:8])=[CH:4][CH:3]=1.[CH:11]([N:14](CC)C(C)C)(C)[CH3:12].BrCC#N>C(#N)C.C(OCC)(=O)C>[F:1][C:2]1[CH:10]=[CH:9][C:5]([CH2:6][CH2:7][NH:8][CH2:12][C:11]#[N:14])=[CH:4][CH:3]=1

Komponenten

6

Edukt 3

HCID 4653p-FluorophenethylamineHCID 11534BromoacetonitrileHCID 81531Diisopropylethylamine

Produkt 1

HCID 21098561HCID 21098561, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6342AcetonitrileLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 4-fluorophenethylamine (1.4 g) in acetonitrile (20 mL) was added dropwise N,N-diisopropylethylamine (2.6 mL) and bromoacetonitrile (0.84 mL). After stirring at room temperature for 50 minutes, the solution was diluted with ethyl acetate, the solution was washed with water, then with saturated sodium chloride water. After drying with anhydrous sodium sulfate, the solvent was removed by evaporation to provide the title compound (2.12 g) as a yellow oily substance.

Aufarbeitung

  1. washthe solution was washed with water
  2. dry with materialAfter drying with anhydrous sodium sulfate
  3. customthe solvent was removed by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-4a0da7085a9d4a9db625dd90774ae72a
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07217723B2

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