反应详情

To a solution of 4-fluorophenethylamine (1.4 g) in acetic acid (10 mL) was added dropwise acetone (0.82 mL) and methanol (20 mL). After sodium cyano-borohydride (0.64 g) was added, and the solution was stirred at room temperature for 2.5 hours. After adding water and diluting with ethyl acetate, the solution was washed with water and saturated sodium chloride water. After drying with anhydrous sodium sulfate, the residue that was obtained upon removing the solvent by evaporation was purified by NAM silica gel column chromatography (hexane/ethyl acetate), and the title compound (0.62 g) was obtained as colorless solids.

1. washthe solution was washed with water and saturated sodium chloride water
2. dry with materialAfter drying with anhydrous sodium sulfate
3. customthe residue that was obtained
4. customupon removing the solvent
5. customby evaporation
6. customwas purified by NAM silica gel column chromatography (hexane/ethyl acetate)