tert-Butanol → [2-(4-Fluoro-3-methoxyphenyl)ethyl]carbamic acid t-butyl ester

Participants

Reaction Steps

3-(4-Fluoro-3-methoxyphenyl)propionic acid (1.98 g), triethylamine (1.67 mL) and diphenylphosphoryl azide (2.59 mL) in t-butanol (20 mL) were heated at 95 to 100° C. for 5 hours. After cooling the reaction solution, the residue that was obtained upon removing the solvent by evaporation was purified by silica gel column chromatography (hexane/ethyl acetate), and the title compound (1.59 g) was obtained as a colorless oily matter.

Provenance & Evidence