反应详情

3-(4-Fluoro-3-methoxyphenyl)propionic acid (1.98 g), triethylamine (1.67 mL) and diphenylphosphoryl azide (2.59 mL) in t-butanol (20 mL) were heated at 95 to 100° C. for 5 hours. After cooling the reaction solution, the residue that was obtained upon removing the solvent by evaporation was purified by silica gel column chromatography (hexane/ethyl acetate), and the title compound (1.59 g) was obtained as a colorless oily matter.

1. temperatureAfter cooling the reaction solution
2. customthe residue that was obtained
3. customupon removing the solvent
4. customby evaporation
5. customwas purified by silica gel column chromatography (hexane/ethyl acetate)