N-Methyl-2-(pyridin-3-YL)ethanamine → 7-Oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid methyl-(2-pyridine-3-vi-ethyl)-amide

HRID 1351271Notes

Reaction equation

HRID 1351271 reaction equation
[CH3:1][NH:2][CH2:3][CH2:4][C:5]1[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=1.[O:11]=[C:12]1[C:17]2[S:18][CH:19]=[C:20]([S:21](Cl)(=[O:23])=[O:22])[C:16]=2[CH2:15][CH2:14][CH2:13]1>>[CH3:1][N:2]([CH2:3][CH2:4][C:5]1[CH:6]=[N:7][CH:8]=[CH:9][CH:10]=1)[S:21]([C:20]1[C:16]2[CH2:15][CH2:14][CH2:13][C:12](=[O:11])[C:17]=2[S:18][CH:19]=1)(=[O:22])=[O:23]

Participants

3

Reactant 2

HCID 5152594N-Methyl-2-(pyridin-3-YL)ethanamineHCID 210986857-Oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-sulfonyl chloride

Product 1

HCID 694166627-Oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid methyl-(2-pyridine-3-vi-ethyl)-amide

Procedure

From methyl-(2-pyridine-3-yl-ethyl)-amine (the compound of Preparation Example 15) (82 mg) and 7-oxo-4,5,6,7-tetrahydro-benzo-[b]thiophene-3-sulfonyl chloride (the compound of Preparation Example 7) (150 mg), the title compound (138 mg) was obtained as a colorless oily matter, in the same way as Preparation Example 41.

Workup

  1. customthe compound of Preparation Example 7) (150 mg)

Sources & evidence

ORD record
ord-f3d2a7536dc940e08028cb717969c2a6
Source dataset
uspto-grants-2007_05
Patent number
US07217723B2

Reaction notes

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