2-(Methylamino)-1-[4-(pyrrolidin-1-yl)phenyl]ethan-1-ol → 7-Oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [2-hydroxy-2-(4-pyrrolidine-1-yl-phenyl)-ethyl]-methyl-amide

HRID 1351280Notes

Reaction equation

HRID 1351280 reaction equation
[CH3:1][NH:2][CH2:3][CH:4]([C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:8][CH:7]=1)[OH:5].[O:17]=[C:18]1[C:23]2[S:24][CH:25]=[C:26]([S:27](Cl)(=[O:29])=[O:28])[C:22]=2[CH2:21][CH2:20][CH2:19]1>>[OH:5][CH:4]([C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:8][CH:7]=1)[CH2:3][N:2]([CH3:1])[S:27]([C:26]1[C:22]2[CH2:21][CH2:20][CH2:19][C:18](=[O:17])[C:23]=2[S:24][CH:25]=1)(=[O:28])=[O:29]

Participants

3

Reactant 2

HCID 210985862-(Methylamino)-1-[4-(pyrrolidin-1-yl)phenyl]ethan-1-olHCID 210986857-Oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-sulfonyl chloride

Product 1

HCID 210986817-Oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [2-hydroxy-2-(4-pyrrolidine-1-yl-phenyl)-ethyl]-methyl-amide

Procedure

From 2-methylamino-1-(4-pyrrolidine-1-yl-phenyl)-ethanol (the compound of Preparation Example 19) (63 mg) and 7-oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonyl chloride (the compound of Preparation Example 7) (70 mg), the title compound (35 mg) was obtained as a colorless amorphous substance, in the same way as Preparation Example 41.

Workup

  1. customthe compound of Preparation Example 7) (70 mg)

Sources & evidence

ORD record
ord-cf226c6c24064da8b32a98d99d0d4e1f
Source dataset
uspto-grants-2007_05
Patent number
US07217723B2

Reaction notes

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