1-Amino-3-(4-chloro-phenoxy)-propan-2-ol → 7-Oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [3-(4-chloro-phenoxy)-2-hydroxy-propyl]-amide

HRID 1351281Notes

Reaction equation

HRID 1351281 reaction equation
[NH2:1][CH2:2][CH:3]([OH:13])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1.[O:14]=[C:15]1[C:20]2[S:21][CH:22]=[C:23]([S:24](Cl)(=[O:26])=[O:25])[C:19]=2[CH2:18][CH2:17][CH2:16]1>>[Cl:12][C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH:3]([OH:13])[CH2:2][NH:1][S:24]([C:23]2[C:19]3[CH2:18][CH2:17][CH2:16][C:15](=[O:14])[C:20]=3[S:21][CH:22]=2)(=[O:25])=[O:26])=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 27708821-Amino-3-(4-chloro-phenoxy)-propan-2-olHCID 210986857-Oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-sulfonyl chloride

Product 1

HCID 210986827-Oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [3-(4-chloro-phenoxy)-2-hydroxy-propyl]-amide

Procedure

From 1-amino-3-(4-chloro-phenoxy)-propane-2-ol (58 mg) and 7-oxo-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonyl chloride (the compound of Preparation Example 7) (70 mg), a yield (45 mg) was obtained as a colorless amorphous substance, in the same way as Preparation Example 41

Workup

  1. customa yield (45 mg)
  2. customwas obtained as a colorless amorphous substance, in the same way as Preparation Example 41

Sources & evidence

ORD record
ord-a60e7abe57f44b1c9f5f20c053accb88
Source dataset
uspto-grants-2007_05
Patent number
US07217723B2

Reaction notes

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