Potassium Acetate → HCID 21098664, compound

HRID 1351288Notes

Reaction equation

HRID 1351288 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]([CH3:25])[S:11]([C:14]2[C:15]3[CH2:22][CH2:21][CH:20](Br)[C:19](=[O:24])[C:16]=3[S:17][CH:18]=2)(=[O:13])=[O:12])=[CH:4][CH:3]=1.[C:26]([O-:29])(=[O:28])[CH3:27].[K+]>CS(C)=O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]([CH3:25])[S:11]([C:14]2[C:15]3[CH2:22][CH2:21][CH:20]([O:29][C:26](=[O:28])[CH3:27])[C:19](=[O:24])[C:16]=3[S:17][CH:18]=2)(=[O:13])=[O:12])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 517044Potassium AcetateHCID 21098666HCID 21098666, compound

Product 1

HCID 21098664HCID 21098664, compoundYield 85.3%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

To a solution of 6-bromo-7-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-sulfonic acid [2-(4-fluorophenyl)ethyl]-methyl-amide (246 mg) in dimethylsulfoxide (2 mL) was added potassium acetate (108 mg). After stirring for 30 minutes, the solution was diluted with, and extracted with ethyl acetate. After drying the organic layer with anhydrous sodium sulfate, the solvent was removed by evaporation to provide the title compound (200 mg) as a yellow oily substance.

Workup

  1. additionthe solution was diluted with, and
  2. extractionextracted with ethyl acetate
  3. dry with materialAfter drying the organic layer with anhydrous sodium sulfate
  4. customthe solvent was removed by evaporation

Sources & evidence

ORD record
ord-22ca6fbd4948444e82f7e1defe9f0c34
Source dataset
uspto-grants-2007_05
Patent number
US07217723B2

Reaction notes

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