Methyl morpholine oxide → HCID 21098660, compound

HRID 1351302Notes

Reaction equation

HRID 1351302 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]([CH3:24])[S:11]([C:14]2[CH:18]=[C:17]([CH:19]([OH:23])[CH:20]([CH3:22])[CH3:21])[S:16][CH:15]=2)(=[O:13])=[O:12])=[CH:4][CH:3]=1.C[N+]1([O-])CCOCC1>ClCCl.[Ru+3].C([N+](CCC)(CCC)CCC)CC>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][N:10]([CH3:24])[S:11]([C:14]2[CH:18]=[C:17]([C:19](=[O:23])[CH:20]([CH3:21])[CH3:22])[S:16][CH:15]=2)(=[O:13])=[O:12])=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 82029Methyl morpholine oxideHCID 866009945-(1-Hydroxy-2-methylpropyl)thiophene-3-sulfonic acid [2-(4-fluorophenyl)ethyl]-methyl-amide

Product 1

HCID 21098660HCID 21098660, compound

Reagents, catalysts & solvents 2

HCID 131726442HCID 131726442, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of 5-(1-hydroxy-2-methylpropyl)thiophene-3-sulfonic acid [2-(4-fluorophenyl)ethyl]-methyl-amide in dichloromethane (2 mL) was added 4 Å molecular sieves (60 mg), N-methyl morpholin-N-oxide (27 mg) and tetrapropyl ammonium ruthenium tetroxide; (n-Pr)4NRuO4 (5 mg). After stirring at room temperature for 1.5 hours, the reaction solution was directly adsorbed onto silica gel, purification by silica gel column chromatography (hexane/ethyl acetate) was carried out, and the title compound (30 mg) was obtained as a yellow oily substance.

Workup

  1. customthe reaction solution was directly adsorbed onto silica gel, purification by silica gel column chromatography (hexane/ethyl acetate)

Sources & evidence

ORD record
ord-549ff56bc4e542e692c8a77aa4c43815
Source dataset
uspto-grants-2007_05
Patent number
US07217723B2

Reaction notes

Loading…