Trifluoroacetic acid → HCID 86600998, compound

HRID 1351310Notes

Reaction equation

C(O[C:6](=O)[N:7]([C:9]1[S:10][C:11]([C:29](=[O:31])[CH3:30])=[CH:12][C:13]=1[S:14](=[O:28])(=[O:27])[N:15]([CH2:17][CH:18]([C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=1)[OH:19])[CH3:16])C)(C)(C)C.FC(F)(F)C(O)=O>>[F:26][C:23]1[CH:22]=[CH:21][C:20]([CH:18]([OH:19])[CH2:17][N:15]([CH3:16])[S:14]([C:13]2[CH:12]=[C:11]([C:29](=[O:31])[CH3:30])[S:10][C:9]=2[NH:7][CH3:6])(=[O:28])=[O:27])=[CH:25][CH:24]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 69415404HCID 69415404, compound

Product 1

HCID 86600998HCID 86600998, compoundYield 91.9%

Procedure

(5-Acetyl-3-{[2-(4-fluorophenyl)-2-hydroxy-ethyl]-methyl-sulfamoyl}-thiophene-2-yl)-methyl-carbamic acid t-butyl ester (600 mg) was treated with trifluoroacetic acid, and the title compound (438 mg) was obtained as a colorless solid, in the same way as Preparation Example 98.

Sources & evidence

ORD record: ord-703c3a66309f497186a445f056a47a58
Source dataset: uspto-grants-2007_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07217723B2

Reaction notes

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