Methyl iodide → HCID 69415500, compound

HRID 1351315Notes

Reaction equation

HRID 1351315 reaction equation
[C:1](=O)([O-])[O-].[K+].[K+].[CH3:7][O:8][C:9]([C:11]1[S:12][CH:13]=[CH:14][C:15]=1[S:16](=[O:28])(=[O:27])[NH:17][CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=1)=[O:10].CI>>[CH3:7][O:8][C:9]([C:11]1[S:12][CH:13]=[CH:14][C:15]=1[S:16](=[O:27])(=[O:28])[N:17]([CH2:18][CH2:19][C:20]1[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=1)[CH3:1])=[O:10]

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 16766382HCID 16766382, compound

Product 1

HCID 69415500HCID 69415500, compound

Procedure

In the presence of potassium carbonate (2.58 g), 3-[2-(4-fluorophenyl)-ethylsulfamoyl]-thiophene-2-carboxylic acid methylester (3.2 g) was reacted with methyl iodide (0.69 mL), and an oily substance (3.38 g) was obtained, in the same way as Preparation Example 52.

Workup

  1. customan oily substance (3.38 g) was obtained, in the same way as Preparation Example 52

Sources & evidence

ORD record
ord-6fe10a1b34b14e6b9a03a2907b3fcba7
Source dataset
uspto-grants-2007_05
Patent number
US07217723B2

Reaction notes

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