(2-(4-Fluorophenyl)ethyl)(methyl)amine → 4-Bromo-thiophene-2-carboxylic acid [2-(4-fluorophenyl)-ethyl]-methyl-amide

HRID 1351322Notes

Reaction equation

HRID 1351322 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:7]([OH:9])=O)[S:5][CH:6]=1.[F:10][C:11]1[CH:16]=[CH:15][C:14]([CH2:17][CH2:18][NH:19][CH3:20])=[CH:13][CH:12]=1>>[F:10][C:11]1[CH:12]=[CH:13][C:14]([CH2:17][CH2:18][N:19]([CH3:20])[C:7]([C:4]2[S:5][CH:6]=[C:2]([Br:1])[CH:3]=2)=[O:9])=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 120234(2-(4-Fluorophenyl)ethyl)(methyl)amineHCID 6104094-Bromo-2-thiophenecarboxylic Acid

Product 1

HCID 866010004-Bromo-thiophene-2-carboxylic acid [2-(4-fluorophenyl)-ethyl]-methyl-amide

Procedure

From 4-bromo-thiophene-2-carboxylic acid and 1.47 g of [2-(4-fluorophenyl)-ethyl]-methyl-amine (the compound of Preparation Example 14) (1.98 g), a colorless solid (2.53 g) was obtained, in the same way as Preparation Example 118-b).

Sources & evidence

ORD record
ord-0d4dc13ef44647b5ae866a555b0c4531
Source dataset
uspto-grants-2007_05
Patent number
US07217723B2

Reaction notes

Loading…