Water → HCID 87825019, compound

HRID 1351333Notes

Reaction equation

HRID 1351333 reaction equation
[CH2:1]([NH:3][C:4]([C:6]1[C:7]2[CH2:14][CH2:13][CH2:12][C:11](=O)[C:8]=2[S:9][CH:10]=1)=[O:5])[CH3:2].[OH2:16].Cl.[NH2:18]O.C([O-])(=O)C.[Na+]>C(O)C>[CH2:1]([NH:3][C:4]([C:6]1[C:7]2[CH2:14][CH2:13][CH2:12]/[C:11](=[N:18]/[OH:16])/[C:8]=2[S:9][CH:10]=1)=[O:5])[CH3:2]

Participants

6

Reactant 4

HCID 962WaterHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 69414409HCID 69414409, compound

Product 1

HCID 87825019HCID 87825019, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

A solution of 7-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ethyl amide (the compound of Preparation Example 115) (96 mg) in ethanol (2 mL) and water (1 mL) was added hydroxylamine.hydrochloride (39 mg) and 46 mg of sodium acetate (46 mg). After heating at 50° C. for 4.5 hours, the reaction solution was cooled to room temperature, the solid that precipitated was collected by filtration, and the title compound (36 mg) was obtained as a colorless solid.

Workup

  1. temperaturethe reaction solution was cooled to room temperature
  2. customthe solid that precipitated
  3. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-0d8cf0b228c4415aa9650063ef4dfe7a
Source dataset
uspto-grants-2007_05
Patent number
US07217723B2

Reaction notes

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