(+-)-alpha-Methyl-alpha-phenylsuccinimide → 3-Methyl-3-phenylpyrrolidine

HRID 1351334Notes

Reaction equation

HRID 1351334 reaction equation
[CH3:1][C:2]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:6][C:5](=O)[NH:4][C:3]1=O.[H-].[Li+].[Al+3].[H-].[H-].[H-]>>[CH3:1][C:2]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:6][CH2:5][NH:4][CH2:3]1

Participants

3

Reactant 2

HCID 92154(+-)-alpha-Methyl-alpha-phenylsuccinimideHCID 21226445Aluminium lithium hydride

Product 1

HCID 210986163-Methyl-3-phenylpyrrolidine

Procedure

3-Methyl-3-phenyl-pyrrolidine, which was synthesized by reducing 3-methyl-3-phenyl pyrrolidine-2,5-dione with aluminum lithium hydride, was used as the amine to carry out the reaction according to <method α>. A purification by silica gel column chromatography (hexane/ethyl acetate) was carried out, and, the title compound (7 mg) was obtained as a colorless solid.

Workup

  1. customA purification by silica gel column chromatography (hexane/ethyl acetate)

Sources & evidence

ORD record
ord-66286f62f78e4d4ebbd21eb86cd45d7a
Source dataset
uspto-grants-2007_05
Patent number
US07217723B2

Reaction notes

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