HCID 58786867, compound → HCID 21098182, compound

HRID 1351389Notes

Reaction equation

HRID 1351389 reaction equation
[C:1]([O:9][C:10]1[C:15](=[O:16])[N:14]([CH3:17])[C:13]([C:18]2([CH3:41])[CH2:23][N:22]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:21][CH2:20][N:19]2C(OCC2C=CC=CC=2)=O)=[N:12][C:11]=1[C:42]([O:44][CH3:45])=[O:43])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCOC(C)=O.[Pd]>[C:1]([O:9][C:10]1[C:15](=[O:16])[N:14]([CH3:17])[C:13]([C:18]2([CH3:41])[CH2:23][N:22]([C:24]([O:26][C:27]([CH3:29])([CH3:30])[CH3:28])=[O:25])[CH2:21][CH2:20][NH:19]2)=[N:12][C:11]=1[C:42]([O:44][CH3:45])=[O:43])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 58786867HCID 58786867, compound

Product 1

HCID 21098182HCID 21098182, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 23938PalladiumSolvent

Procedure

1-Benzyl 4-tert-butyl 2-[5-(benzoyloxy)-4-(methoxycarbonyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]-2-methylpiperazine-1,4-dicarboxylate was dissolved in AcOEt (20 ml/mmol) and hydrogenated at atm pressure on 10% (w/w) Pd/C over night. After filtration of the catalyst, solvent was evaporated to give crude product.

Workup

  1. filtrationAfter filtration of the catalyst, solvent
  2. customwas evaporated
  3. customto give crude product

Sources & evidence

ORD record
ord-7e04143b63c54957816f5790eb5282d3
Source dataset
uspto-grants-2007_05
Patent number
US07217713B2

Reaction notes

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