3-Nitrophenylacetonitrile → (3-Amino-phenyl)-acetonitrile

Participants

Reaction Steps

3-Nitrophenylacetonitrile (6.87 g, 42 mmol) and tin(II)chloride dihydrate (50 g, 220 mmol) in ethyl acetate (125 ml) were stirred at room temperature for 72 hours. The reaction was diluted with ethyl acetate and saturated aqueous sodium bicarbonate solution was added. The resulting precipitate was filtered off and the filtrate extracted with ethyl acetate (3×). The combined organic solutions were dried (MgSO4), filtered and evaporated under reduced pressure to afford the title compound as a pale yellow oil, 5.33 g.

Provenance & Evidence