反应详情

3-Nitrophenylacetonitrile (6.87 g, 42 mmol) and tin(II)chloride dihydrate (50 g, 220 mmol) in ethyl acetate (125 ml) were stirred at room temperature for 72 hours. The reaction was diluted with ethyl acetate and saturated aqueous sodium bicarbonate solution was added. The resulting precipitate was filtered off and the filtrate extracted with ethyl acetate (3×). The combined organic solutions were dried (MgSO4), filtered and evaporated under reduced pressure to afford the title compound as a pale yellow oil, 5.33 g.

1. additionwas added
2. filtrationThe resulting precipitate was filtered off
3. extractionthe filtrate extracted with ethyl acetate (3×)
4. dry with materialThe combined organic solutions were dried (MgSO4)
5. filtrationfiltered
6. customevaporated under reduced pressure