Hydrochloric Acid → HCID 69040941, compound

Participants

Reaction Steps

To a cooled at 0° C. solution of N-Boc-L-proline 3-nitrooxypropyl ester (2.1 g, 6.6 mmol) in Ethyl acetate (50 mL) a 6.8 M solution of HCl in ethyl acetate (19.4 mL) was added and the solution was slowly warmed to room temperature and stirred for 5 hours. Then the solvent was evaporated affording L-proline 3-nitrooxypropyl ester hydrochloride (1.7 g, quantitative) as a foam.

Provenance & Evidence