Hydrochloric Acid → HCID 69040941, compound

HRID 1351419Notes

Reaction equation

HRID 1351419 reaction equation
[N+:1]([O:4][CH2:5][CH2:6][CH2:7][O:8][C:9](=[O:22])[C@@H:10]1[CH2:14][CH2:13][CH2:12][N:11]1C(OC(C)(C)C)=O)([O-:3])=[O:2].[ClH:23]>C(OCC)(=O)C>[ClH:23].[N+:1]([O:4][CH2:5][CH2:6][CH2:7][O:8][C:9](=[O:22])[C@@H:10]1[CH2:14][CH2:13][CH2:12][NH:11]1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21099365HCID 21099365, compound

Product 1

HCID 69040941HCID 69040941, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a cooled at 0° C. solution of N-Boc-L-proline 3-nitrooxypropyl ester (2.1 g, 6.6 mmol) in Ethyl acetate (50 mL) a 6.8 M solution of HCl in ethyl acetate (19.4 mL) was added and the solution was slowly warmed to room temperature and stirred for 5 hours. Then the solvent was evaporated affording L-proline 3-nitrooxypropyl ester hydrochloride (1.7 g, quantitative) as a foam.

Workup

  1. additionwas added
  2. customThen the solvent was evaporated

Sources & evidence

ORD record
ord-111f5229f5e242e1a8665614fe9cce57
Source dataset
uspto-grants-2007_05
Patent number
US07217733B2

Reaction notes

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