Dichloromethane → HCID 69040905, compound

HRID 1351421Notes

Reaction equation

HRID 1351421 reaction equation
[N+:1]([O:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10](=[O:23])[C@@H:11]1[CH2:15][CH2:14][CH2:13][N:12]1C(OC(C)(C)C)=O)([O-:3])=[O:2].C(Cl)[Cl:25]>>[ClH:25].[N+:1]([O:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10](=[O:23])[C@@H:11]1[CH2:15][CH2:14][CH2:13][NH:12]1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 21099367HCID 21099367, compound

Product 1

HCID 69040905HCID 69040905, compound

Procedure

N-Boc-L-proline 4-nitrooxybutyl ester (1.24 g, 3.7 mmol) was dissolved in CH2Cl2 (20 mL) and HCl gas was bubbled into the solution for 2 hours. Then the mixture was concentrated, affording L-proline 4-nitrooxybutyl ester hydrochloride as a clear oil (1.00 g, quantitative).

Workup

  1. customHCl gas was bubbled into the solution for 2 hours
  2. concentrationThen the mixture was concentrated

Sources & evidence

ORD record
ord-ad4cac4e5d9d49d58399624364e8e53c
Source dataset
uspto-grants-2007_05
Patent number
US07217733B2

Reaction notes

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