3,3-Dimethyl-1-butanol → 3,3-Dimethyl-1-butyl 5-amino-4-oxopentanoate Hydrochloride

HRID 1351428Notes

Reaction equation

HRID 1351428 reaction equation
[CH3:1][C:2]([CH3:7])([CH3:6])[CH2:3][CH2:4][OH:5].[ClH:8].[NH2:9][CH2:10][C:11](=[O:17])[CH2:12][CH2:13][C:14](O)=[O:15]>>[ClH:8].[NH2:9][CH2:10][C:11](=[O:17])[CH2:12][CH2:13][C:14]([O:5][CH2:4][CH2:3][C:2]([CH3:7])([CH3:6])[CH3:1])=[O:15]

Participants

3

Reactant 2

HCID 122333,3-Dimethyl-1-butanolHCID 123608Aminolevulinic Acid Hydrochloride

Product 1

HCID 574382533,3-Dimethyl-1-butyl 5-amino-4-oxopentanoate Hydrochloride

Procedure

From 3,3-dimethyl-1-butanol (5.0 g; 49 mmol) and 5-amino-4-oxopentanoic acid hydrochloride (1.0 g; 6.0 mmol) at 70° C. The reaction was complete after 4 h. The yield was 0.91 g (60%), mp146–148°.

Workup

  1. customat 70° C

Sources & evidence

ORD record
ord-dbc3cf343c5c497bb66d269b56055d91
Source dataset
uspto-grants-2007_05
Patent number
US07217736B2

Reaction notes

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