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HRID1351454

反应详情

EQUATION

反应方程式

HRID 1351454 的结构方程式

REACTANTS

反应物

2
结构：CC(C)c1cc(C=O)cc(C(C)C)c1O
HCID82712

4-Hydroxy-3,5-bis(isopropyl)benzaldehyde

C13H18O2

结构：N#CCS(=O)(=O)CC#N
HCID142163

Sulphonyl diacetonitrile

C4H4N2O2S

PRODUCTS

生成物

1
结构：CC(C)c1cc(/C=C(\C#N)S(=O)(=O)CC#N)cc(C(C)C)c1O
HCID9905645

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：C1CCNCC1
催化剂HCID8082

Piperidine

C5H11N

结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A mixture of 500 mg of 3,5-diisopropyl-4-hydroxybenzaldehyde and 700 mg of sulfonyl diacetonitrile in 6 ml of ethanol was refluxed with a few drops of piperidine for 4 hours. Ethanol was removed in a rotavap and the mixture worked up with ethyl acetate, diluted acid and brine. A portion of the crude was then purified by HPLC on a C-18 column to provide 50 mg of M27 along with 30 mg of M29.

WORKUP

后处理

  1. customEthanol was removed in a rotavap
  2. additiondiluted acid and brine
  3. customA portion of the crude was then purified by HPLC on a C-18 column
  4. customto provide 50 mg of M27 along with 30 mg of M29