Formamide → 6-methylquinazolin-4-ol

HRID 1351465Notes

Reaction equation

HRID 1351465 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:11])=[C:6]([CH:10]=1)[C:7](O)=[O:8].[CH:12]([NH2:14])=O>O>[CH3:1][C:2]1[CH:10]=[C:6]2[C:5](=[CH:4][CH:3]=1)[N:11]=[CH:12][NH:14][C:7]2=[O:8]

Participants

4

Reactant 2

HCID 713FormamideHCID 762552-Amino-5-methylbenzoic acid

Product 1

HCID 1354524426-methylquinazolin-4-ol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

8 g of 5-methyl 2-aminobenzoic acid and 15 ml formamide was heated at −170° C. 1.5 hour. Water was added and the solid filtered to give 7.3 g of 6-methyl 4-quinazolinone as a light brown-white solid, mp—268° C.

Workup

  1. custom1.5 hour
  2. filtrationthe solid filtered

Sources & evidence

ORD record
ord-e441a7bc50174f1db99b2c2344b810db
Source dataset
uspto-grants-2007_05
Patent number
US07217737B2

Reaction notes

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