Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1-(2-Chloroethyl)-4-fluorobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4-Fluorophenethyl Alcohol | HCID 82068 | — |
| 반응물 | Tricaprylylmethyl ammonium chloride | HCID 77620884 | — |
| 용매 | Chlorobenzene | HCID 7964 | — |
| 생성물 | 1-(2-Chloroethyl)-4-fluorobenzene | HCID 67622 | — |
반응 단계
A mixture of 7 g 2-(4-fluoro-phenyl)-ethanol, 25 mL of chlorobenzene, 42 mL of 37% HCl, and 0.9 g of Aliquot® 336 (tricaprylylmethyl ammonium chloride) was heated to reflux for 3 days, cooled and extracted into 3×100 mL of hexane. The combined extracts were dried over magnesium sulfate and concentrated under reduced pressure. The resulting oil was mainly 1-(2-chloro-ethyl)-4-fluoro-benzene:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07217716B2 |
| 출처 데이터셋 | uspto-grants-2007_05 |
| ORD ID | ord-5c9be65b8d1a455e87d3baf185718e36 |
| 출처 메모 | uspto-grants-2007_05 |