反应详情

A mixture of 7 g 2-(4-fluoro-phenyl)-ethanol, 25 mL of chlorobenzene, 42 mL of 37% HCl, and 0.9 g of Aliquot® 336 (tricaprylylmethyl ammonium chloride) was heated to reflux for 3 days, cooled and extracted into 3×100 mL of hexane. The combined extracts were dried over magnesium sulfate and concentrated under reduced pressure. The resulting oil was mainly 1-(2-chloro-ethyl)-4-fluoro-benzene:

1. temperaturewas heated
2. temperatureto reflux for 3 days
3. temperaturecooled
4. extractionextracted into 3×100 mL of hexane
5. dry with materialThe combined extracts were dried over magnesium sulfate
6. concentrationconcentrated under reduced pressure