関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 反応物 | Benzyl 4-acetylpiperidine-1-carboxylate | HCID 19065050 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 4-(1-Hydroxyimino-ethyl)-piperidine-1-carboxylic acid benzyl ester | HCID 74064235 | — |
反応手順
A mixture of 4.0 g of 4-acetyl-piperidine-1-carboxylic acid benzyl ester, 25 mL of pyridine, and 6 g of hydroxylamine hydrochloride were heated to 100° C. for 12 h. The mixture was concentrated under reduced pressure and partitioned between 200 mL of ethyl acetate and 50 mL of 1N HCl. The organic extract was dried over magnesium sulfate and concentrated to dryness under reduced pressure. Drying under vacuum gave 4-(1-hydroxyimino-ethyl)-piperidine-1-carboxylic acid benzyl ester as a solid:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07217716B2 |
|---|
| 出典データセット | uspto-grants-2007_05 |
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| ORD ID | ord-29df7c429f6b49b98a222f702c749228 |
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| 出典メモ | uspto-grants-2007_05 |
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