反应详情

温度

100 °C

A mixture of 4.0 g of 4-acetyl-piperidine-1-carboxylic acid benzyl ester, 25 mL of pyridine, and 6 g of hydroxylamine hydrochloride were heated to 100° C. for 12 h. The mixture was concentrated under reduced pressure and partitioned between 200 mL of ethyl acetate and 50 mL of 1N HCl. The organic extract was dried over magnesium sulfate and concentrated to dryness under reduced pressure. Drying under vacuum gave 4-(1-hydroxyimino-ethyl)-piperidine-1-carboxylic acid benzyl ester as a solid:

1. concentrationThe mixture was concentrated under reduced pressure
2. custompartitioned between 200 mL of ethyl acetate and 50 mL of 1N HCl
3. extractionThe organic extract
4. dry with materialwas dried over magnesium sulfate
5. concentrationconcentrated to dryness under reduced pressure
6. customDrying under vacuum