7H-Purine, 6-chloro-7-methyl- → (7-Methyl-7H-purin-6-yl)-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amine

HRID 1351556Notes

Reaction equation

HRID 1351556 reaction equation
[C:1]1([CH2:7][CH2:8][S:9]([N:12]2[CH2:17][CH2:16][CH:15]([CH2:18][NH2:19])[CH2:14][CH2:13]2)(=[O:11])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:21]1[N:29]=[CH:28][N:27]=[C:26]2[C:22]=1[N:23]([CH3:30])[CH:24]=[N:25]2>>[CH3:30][N:23]1[C:22]2[C:26](=[N:27][CH:28]=[N:29][C:21]=2[NH:19][CH2:18][CH:15]2[CH2:14][CH2:13][N:12]([S:9]([CH2:8][CH2:7][C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)(=[O:10])=[O:11])[CH2:17][CH2:16]2)[N:25]=[CH:24]1

Participants

3

Reactant 2

HCID 950577H-Purine, 6-chloro-7-methyl-2×HCID 22135729[1-(2-Phenylethylsulfonyl)piperidin-4-yl]methanamine

Product 1

HCID 23577259(7-Methyl-7H-purin-6-yl)-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amine

Procedure

EXAMPLE 85 was prepared from C-[1-(2-phenyl-ethanesulfonyl)-piperidin-4-yl]-methylamine and 6-chloro-7-methyl-7H-purine (6-chloro-7-methyl-7H-purine was prepared according to G. B. Eilon, J. Org. Chem., 27:2478–2491(1962): MS (m+1)=415.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-2176bf4f45d64aa88153fdd48c30ad86
Source dataset
uspto-grants-2007_05
Patent number
US07217716B2

Reaction notes

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